Abstract:Donghe sandstone is currently major target for exploration in Tazhong area of Tarim Basin.Through introduction of distribution and structural characters for Donghe sandstone formation and analysis of basic petroleum geologic conditions(such as source rock,reservoir,cap formation,seal condition and other necessary condition,etc),the paper considered that Donghe sandstone has a substantial ex-ploration potential.At same time, the paper also pointed out that left-lateral strike-slip fault in Indo-China-Yanshan Mountain Stage does destruction to reservoir;igneous rock in central part of Tazhong area is favorable for oil-gas accumulation.The oil-sealing function of thin-away line of Donghe sandstone in east part of Tazhong area is still waiting for further determination.